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This book will provide the latest advances in molecular and cellular biology for establishing the foundation of a complete understanding of the mechanisms of breast differentiation leading to cancer prevention. The authors are based on the epidemiological evidence indicating that early first full term pregnancy is a protective factor in human against breast cancer and they have used this paradigm and developed experimental systems in both in vivo and in vitro that have demonstrated mechanistically how the differentiation at the organ and cellular level takes place. This knowledge has provided the blueprint for developing better understanding of the basis of cancer prevention. The transcriptoma analysis of the breast of pre and post-menopausal women has established a genomic signature imprinted in the breast that differs according to the reproductive history of the woman showing that early first full term pregnancy reprogram the organ. This reprogramming takes place at the chromatin level by changing the transcriptional process. The modification of the transcriptional control is due to the expression of non coding RNA sequences and posttranscriptional control driven by the splicesome. The plasticity of the genome of the human breast make possible this reprogramming that is not only induced by the physiological process of pregnancy but by the use of hormones that mimic pregnancy without pregnancy. The author have established the basis of clinical trials for prevention and the discovery that short 15aa peptides of the chorionic gonadotropin hormone can be used in human breast cancer prevention based on preclinical and clinical data. The Role of Carbohydrate Restriction in Cancer - Medscape Is There a Role for Carbohydrate Restriction in the Treatment and Prevention of Cancer? Rainer J Klement; Ulrike Kmmerer Disclosures. Nutr Metab. 2011;8(75) OMIM Entry - 114480 - BREAST CANCER Breast cancer (referring to mammary carcinoma not mammary sarcoma) is histopathologically and almost certainly etiologically and genetically heterogeneous. Important ... Obesity-associated NLRC4 inflammasome activation drives ... Obesity is associated with higher breast cancer risk and poor prognosis. Here the authors show that obesity promotes breast cancer through the recruitment of ... Triple-Negative Breast Cancer NEJM Triple-negative breast cancer so called because it lacks expression of the estrogen receptor progesterone receptor and HER2 is often but not always a basal-like ... Cancer in Animals - Veterinary Oncology CancerIndex Home Specialty Veterinary Oncology. Veterinary Oncology. Cancer is an uncontrolled growth of abnormal cells. It is found in animals as well as humans. Funded Grants - Cancer Prevention Research Institute of Texas Funded Grants. Texas leads the nation in its commitment to the war on cancer. CPRIT has funded 1123 awards for cancer research product development and prevention ... Cellular & Molecular Immunology - The role of gut ... Top of page The role of the microbiota in postnatal development of innate and adaptive immunity and the mucosal barrier. The close symbiosis of the microbiota and ... Breast Cancer Cancer Genetics Web The transcriptomic profiles of human breast cancer cell lines MCF-7 and MDA-MB-435 were investigated using the next-generation RNA sequencing (RNA-Seq). Vicente Valero M.D. F.A.C.P. - Breast Medical Oncology ... Dr. Valero utilizes a multidisciplinary approach to the treatment of breast cancer. His research interests include breast neoplasms unusual histologies new drug ... Exemestane for Breast-Cancer Prevention in Postmenopausal ... Original Article. Exemestane for Breast-Cancer Prevention in Postmenopausal Women. Paul E. Goss M.D. Ph.D. James N. Ingle M.D. Jos E. Als-Martnez M.D. Ph ...
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